Whole-Cell Thermal Sensor for the Detection of P. falciparum-Infected Erythrocytes: Imprinted Polymers as Synthetic Receptors for the Detection of Malaria

• DOI: 10.1021/acssensors.4c02706
• Publication Date: 2025-01-16T18:42:13Z
• Authors: Rocio Arreguin-Ca...; Ramayana M. Medei...; Ana Rafaela Antun...; Augusto César Par...; Lilian Lacerda Bueno; Ricardo Toshio Fu...; Hanne Diliën; Thomas J. Cleij; Kasper Eersels; Bart van Grinsven
• Keywords: Molecularly imprinted polymer

Malaria is a major public healthcare concern worldwide, representing leading cause of death in specific regions. The gold standard for diagnosis microscopic analysis, but this requires laboratory setting, trained staff, and infrastructure therefore typically slow dependent on the experience technician. This study introduces, first time, biomimetic sensing platform direct detection disease. heart sensor consists synthetic receptor created by surface imprinting Plasmodium falciparum-infected erythrocytes polymeric matrix. layer coupled to low-cost fast thermal transducer platform, allowing real time infection. artificial composite poly(dimethylsiloxane) graphene oxide that, combination with readout, exhibited limit below 0.5% parasitemia erythrocyte samples. value relevant infection patients low levels. proves that sensors could be further explored development point-of-care technologies management