Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells

• DOI: 10.1021/acssensors.6b00490
• Publication Date: 2016-11-17T10:25:09Z
• Authors: Shuwei Zhang; Rashmi Adhikari; Mingxi Fang; Nethaniah Dorh; Cong Li; Meghnath Jaishi; Jingtuo Zhang; Ashutosh Tiwari; Ranjit Pati; Fen-Tair Luo; Haiying Liu
• Keywords: Stokes shift; Metalloprotein

We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide an effective three-nitrogen-atom one-oxygen-atom binding motif. large Stokes shifts offer sensitive selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring concentration changes in living cells, detecting intracellular released from metalloproteins.