Metabolic Engineering of Corynebacterium glutamicum for the Production of the Four-Carbon Platform Chemicals γ-Hydroxybutyrate and γ-Butyrolactone

• DOI: 10.1021/acssynbio.4c00603
• Publication Date: 2024-10-22T18:50:41Z
• Authors: Fanghuan Zhu; Nan Qin; Xuecong Cen; Yufei Dong; Dehua Liu; Zhen Chen
• Keywords: Corynebacterium glutamicum; Metabolic Engineering; Synthetic Biology; Industrial microbiology; Corynebacterium; Carbon fibers; Carbon source

γ-Hydroxybutyrate (GHB) is an important C4 platform chemical, serving as a crucial precursor for the synthesis of various bulk chemicals, including γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BDO). In this study, we report systematic metabolic engineering