Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

• DOI: 10.1021/bc900144m
• Publication Date: 2009-05-13T16:51:14Z
• Authors: Ling-Yan Tang; Yu-Cai Wang; Yang Li; Jin-Zhi Du; Jun Wang
• Keywords: Drug Carriers; Polyesters; Intracellular Space; Biological Transport; 01 natural sciences; Phosphates; 0104 chemical sciences; 3. Good health; Doxorubicin; Cell Line, Tumor; Humans; Disulfides; Micelles; Cell Proliferation

Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, disulfide-linked biodegradable diblock copolymer poly(ε-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin aqueous solution but detached the shell material under stimulus, resulting rapid destruction structure. These glutathione-sensitive also rapidly released molecules intracellularly led to enhanced growth inhibition A549 suggesting that this may have potential improving delivery efficacy.