Structure and Thermodynamical Properties of Metformin Salicylate

• DOI: 10.1021/cg400150f
• Publication Date: 2013-02-25T20:08:07Z
• Authors: R. Pérez-Fernández; N. Fresno; P. Goya; J. Elguero; L. Menéndez-Taboada; S. García-Granda; C. Marco
• Keywords: Cocrystal

The behavior under thermal conditions of the cocrystal formed by metformin and salicylic acid was studied DSC, crystallography (single-crystal), powder diffraction (WAXS). Metformin salicylate crystallizes in space group P21/c, with anion showing a planar structure, stabilized strong intramolecular hydrogen bonds. more flexible cations link through oxygen atoms salicylate, forming dense hydrogen-bonding network. compound exists initially as salt, but after melting cooling, it is transformed into glass form that melts again, different behaviors depending on heating rate.