Functionalizable Organic Nanochannels Based on Lipid Nanotubes: Encapsulation and Nanofluidic Behavior of Biomacromolecules

• DOI: 10.1021/cm070626p
• Publication Date: 2007-06-09T12:01:21Z
• Authors: Naohiro Kameta; Mitsutoshi Masuda; Hiroyuki Minamikawa; Yumiko Mishima; Ichiro Yamashita; Toshimi Shimizu
• Keywords: Encapsulation; Nanofluidics

The amino groups on the inner surface of nanotube that was self-assembled from unsymmetrical bolaamphiphile, N-(2-aminoethyl)-N'-(β-d-glucopyranosyl)-icosanediamide 1, were modified covalently with a fluorescence donor dye. This functionalization surfaces has allowed us to achieve construction an optical recognition system for encapsulation guest molecules. Fluorescence resonance energy transfer (FRET) located ferritin labeled acceptor enabled visualize and nanofluidic features in nanochannel shaped by hollow cylinder structure. By using this system, we able estimate diffusion constants gold nanoparticles organic nanochannels basis lipid nanotubes. We have also demonstrated size charge strongly affect behavior toward biomacromolecules such as DNA spherical proteins.