Recent Advances in Asymmetric Catalysis in Flow

• DOI: 10.1021/cs300830x
• Publication Date: 2013-03-19T16:36:35Z
• Authors: Dongbo Zhao; Kuiling Ding
• Keywords: Microreactor; Homogeneous Catalysis; Kinetic resolution; Flow chemistry

Asymmetric catalysis in flow has been attracting much attention very recently because of the potential advantages over its batchwise counterpart, such as high-throughput screening and synthesis, easy automation with integration on-demand reaction analysis, little or no workup, long-term use catalysts case heterogeneous catalysis. Homogeneous asymmetric performed a microreactor demonstrated successful examples fast catalyst screening, integrated inline/onlineanalysis, microflow photocatalysis, multistep transformation unstable intermediates, for lower loading homogeneous recylcing. Since serves better way than analogue separation recycling, this Review Article summarizes recent development via different immobilization methods, covalent support, self-supported method, an adsorption H-bonding, electrostatic ionic interaction, nonconventional media, well. In addition, biocatalysis, including enzyme-catalyzed kinetic resolution transformation, will be discussed either mode.