Highly Enantioselective Aerobic Oxidation of α-Hydroxyphosphonates Catalyzed by Chiral Vanadyl(V) Methoxides Bearing N-Salicylidene-α-aminocarboxylates

• DOI: 10.1021/ja060639o
• Publication Date: 2006-05-10T04:48:58Z
• Authors: Vijay D. Pawar; Sampada Bettigeri; Shiue-Shien Weng; Jun-Qi Kao; Chien-Tien Chen
• Keywords: Oxygen; Leucine; Organophosphonates; Stereoisomerism; Amino Acids; Vanadates; Oxidation-Reduction; 01 natural sciences; Catalysis; 0104 chemical sciences

An unprecedented vanadyl(V) methoxide complex 4 derived from 3,5-dibromo-N-salicylidene-l-tert-leucinate enables highly enantioselective aerobic oxidations of α-hydroxyphosphonates at ambient temperature with selectivity factors ranging 3 to >99.