Formation of a Mesoscopic Skin Barrier in Mesoglobules of Thermoresponsive Polymers

• DOI: 10.1021/ja201217d
• Publication Date: 2011-06-10T18:14:57Z
• Authors: Matthias J. N. Junk; Wen Li; A. Dieter Schlüter; Gerhard Wegner; Hans W. Spiess; Afang Zhang; Dariush Hinderberger
• Keywords: Mesoscopic physics

With the combination of molecular scale information from electron paramagnetic resonance (EPR) spectroscopy and meso-/macroscopic various other characterization techniques, formation mesoglobules thermoresponsive dendronized polymers is explained. Apparent differences in EPR spectra dependence heating rate, chemical nature dendritic substructure polymer, concentration are interpreted to be caused by a dense polymeric layer at periphery mesoglobule. This skin barrier formed narrow temperature range ~4 K above T(C) prohibits release molecules that incorporated polymer aggregate. In large mesoglobules, low rates high concentrations, considerable amount water entrapped microphase-separates collapsed chains temperatures. results aggregates possessing an aqueous core corona consisting chains. A fast concentration, hydrophobic subunits side make entrapment less favorable lead higher degree vitrification. may bear consequences for design use systems growing field drug delivery.