Selective Chromium(VI) Ligands Identified Using Combinatorial Peptoid Libraries

• DOI: 10.1021/ja408788t
• Publication Date: 2013-11-06T18:30:57Z
• Authors: Abigail S. Knight; Effie Y. Zhou; Jeffrey G. Pelton; Matthew B. Francis
• Keywords: Peptoid; Hexavalent Chromium

Hexavalent chromium [Cr(VI)] is a worldwide water contaminant that currently without cost-effective and efficient remediation strategies. This in part due to lack of ligands can bind it amid an excess innocuous ions aqueous solution. We present herein the design application peptoid-based library ligand candidates for toxic metal ions. A selective screening process was used identify members Cr(VI) species at neutral pH presence large spectator There were 11 sequences identified, their affinities compared using titrations monitored with UV–vis spectroscopy. To interactions involved coordination specificity, we evaluated effects sequence substitutions backbone variation highest affinity structure. Additional characterization complex formed between this performed NMR evaluate ability developed remediate contaminated solutions, structures synthesized on solid-phase resin incubated environmental samples contained simulated levels contamination. The synthetic demonstrated reduce amount within range EPA contamination guidelines. In addition providing some first Cr(VI), these studies highlight promise peptoid as easily prepared components materials.