Time-Resolved Ion Mobility Mass Spectrometry to Solve Conformational Changes in a Cryptochrome

• DOI: 10.1021/jacs.3c13818
• Publication Date: 2024-05-17T07:53:35Z
• Authors: Rene Zangl; Sejla Soravia; Martin Saft; Jan Gerrit Löffler; Jonathan Schulte; Christian Joshua ...; Jens Bredenbeck; Lars-Oliver Essen; Nina Morgner
• Keywords: Ion-mobility spectrometry

Many biological mechanisms rely on the precise control of conformational changes in proteins. Understanding such dynamic processes requires methods for determining structures and their temporal evolution. In this study, we introduce a novel approach to time-resolved ion mobility mass spectrometry. We validated method simple photoreceptor model applied it more complex system, animal-like cryptochrome from