Selective Hydrofunctionalization of Alkenyl Fluorides Enabled by Nickel-Catalyzed Hydrogen Atoms and Group Transfer: Reaction Development and Mechanistic Study

• DOI: 10.1021/jacs.4c01506
• Publication Date: 2024-04-15T22:02:50Z
• Authors: Fan Chen; Qianwei Zhang; Yingying Li; Zhi-Xiang Yu; Lingling Chu

Due to the unique effect of fluorine atoms, efficient construction high-value alkyl fluorides has attracted significant interest in modern drug development. However, enantioselective catalytic strategies for assembly highly functionalized chiral C(sp