Three-in-One: Sensing, Self-Assembly, and Cascade Catalysis of Cyclodextrin Modified Gold Nanoparticles

• DOI: 10.1021/jacs.6b07590
• Publication Date: 2016-12-07T19:22:20Z
• Authors: Yan Zhao; Yucheng Huang; Hui Zhu; Qingqing Zhu; Yunsheng Xia
• Keywords: Glucose oxidase; Horseradish peroxidase; Dispersity; Gluconic acid

We herein present a three-in-one nanoplatform for sensing, self-assembly, and cascade catalysis, enabled by cyclodextrin modified gold nanoparticles (CD@AuNPs). Monodisperse AuNPs 15–20 nm in diameter are fabricated an eco-friendly way the proposed one-step colloidal synthesis method using CD as both reducing agents stabilizers. First, as-prepared employed not only scaffolds but energy acceptors turn-on fluorescent sensing based on guest replacement reaction. Then, macrocyclic supramolecule functionalized can be controllably assembled form well-defined one- two-dimensional architectures tetrakis(4-carboxyphenyl)porphyrin mediator. Finally, addition to conventional host–guest interaction properties, CD@AuNPs possess unpredictable catalytic activity exhibit mimicking properties of glucose oxidase horseradish peroxidase simultaneously. Especially, reaction (glucose is first catalytically oxidized generates gluconic acid H2O2; then enzymatic H2O2 preadded TMB (3,3′,5,5′-tetramethylbenzidine) further catalyzed into H2O oxTMB, respectively) well-achieved sole catalyst. By employing joint experimental–theoretical study, we reveal that unique probably derive from special topological structures molecules resulting electron transfer effect AuNP surface appended molecules.