A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows

• DOI: 10.1021/jacs.7b07818
• Publication Date: 2017-10-24T12:07:24Z
• Authors: Han Lin; Shanshan Gao; Chen Dai; Yu Chen; Jianlin Shi
• Keywords: MXenes; Biocompatibility

Conventionally, ceramics-based materials, fabricated by high-temperature solid-phase reaction and sintering, are preferred as bone scaffolds in hard-tissue engineering because of their tunable biocompatibility mechanical properties. However, possible biomedical applications have rarely been considered, especially the cancer phototherapeutic both first second near-infrared light (NIR-I NIR-II) biowindows. In this work, we explore, for time far know, a novel kind 2D niobium carbide (Nb2C), MXene, with highly efficient vivo photothermal ablation mouse tumor xenografts NIR-I NIR-II windows. The Nb2C nanosheets (NSs) were facile scalable two-step liquid exfoliation method combining stepwise delamination intercalation procedures. ultrathin, lateral-nanosized NSs exhibited extraordinarily high conversion efficiency (36.4% at 45.65% NIR-II), well stability. intrinsically feature unique enzyme-responsive biodegradability to human myeloperoxidase, low phototoxicity, biocompatibility. Especially, these surface-engineered present eradication This work significantly broadens application prospects MXenes rationally designing compositions exploring related physiochemical properties, on phototherapy cancer.