Deformable Hollow Periodic Mesoporous Organosilica Nanocapsules for Significantly Improved Cellular Uptake

• DOI: 10.1021/jacs.7b10694
• Publication Date: 2017-12-27T16:58:30Z
• Authors: Zhaogang Teng; Chunyan Wang; Yuxia Tang; Wei Li; Lei Bao; Xuehua Zhang; Xiaodan Su; Fan Zhang; Junjie Zhang; Shouju Wang; Dongyuan Zhao; Guangming Lu
• Keywords: Nanocapsules; Mesoporous organosilica

Mesoporous solids have been widely used in various biomedical areas such as drug delivery and tumor therapy. Although deformability has recognized a prime important characteristic influencing cellular uptake, the synthesis of deformable mesoporous is still great challenge. Herein, thioether-, benzene-, ethane-bridged hollow periodic organosilica (HPMO) nanocapsules successfully synthesized for first time by preferential etching approach. The prepared HPMO possess uniform diameters (240-310 nm), high surface (up to 878 m2·g-1), well-defined mesopores (2.6-3.2 large pore volumes (0.33-0.75 m3·g-1). Most importantly, simultaneously cavities (164-270 thin shell thicknesses (20-38 abundant organic moiety shells, which endow lower Young's modulus (EY) 3.95 MPa than that solid PMO nanoparticles (251 MPa). HPMOs with low EY are intrinsically flexible solution, well-characterized liquid cell electron microscopy. More interestingly, it found can easily enter into human breast cancer MCF-7 cells via spherical-to-oval morphology change, resulting 26-fold enhancement uptake (43.1% internalized versus 1.65% counterparts). were further loaded anticancer doxorubicin (DOX), shows killing effects cells, demonstrating promise applications.