Fluorine Grafted Cu7S4–Au Heterodimers for Multimodal Imaging Guided Photothermal Therapy with High Penetration Depth

• DOI: 10.1021/jacs.8b00368
• Publication Date: 2018-04-20T18:14:18Z
• Authors: Jiabin Cui; Rui Jiang; Chang Guo; Xilin Bai; Suying Xu; Leyu Wang
• Keywords: Penetration (warfare)

We report the multifunctional nanocomposites (NCs) consisting of 19F-moieties grafted Cu7S4–Au nanoparticles (NPs) for negligible background 19F-magnetic resonance imaging (19F-MRI) and computed tomography (CT) guided photothermal therapy. The localized surface plasmon (LSPR) absorption can be reasonably tuned to in vivo transparent window (800–900 nm) by coupling Au (<10 nm, LSPR ∼530 with Cu7S4 (<15 ∼1500 into heterodimers. tests show that deeper light penetration 808 nm irradiation, better efficacy, less damage normal tissues than 1500 irradiation. Moreover, compared traditional 1H-MRI, 19F-MRI based on these NCs demonstrates much sensitivity due background. This work offers a promising strategy multimodal therapy deep tissue good efficacy.