Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

• DOI: 10.1021/jacs.8b01072
• Publication Date: 2018-04-18T04:39:03Z
• Authors: Guangxu Lan; Kaiyuan Ni; Ziwan Xu; Samuel S. Veroneau; Yang Song; Wenbin Lin
• Keywords: Cancer Immunotherapy; Hypoxia; Cancer Therapy

Immunotherapy has become a promising cancer therapy, but only works for subset of patients. Immunogenic photodynamic therapy (PDT) can prime immunotherapy to increase the response rates, its efficacy is severely limited by tumor hypoxia. Here we report nanoscale metal-organic framework, Fe-TBP, as novel nanophotosensitizer overcome hypoxia and sensitize effective PDT, priming non-inflamed tumors immunotherapy. Fe-TBP was built from iron-oxo clusters porphyrin ligands sensitized PDT under both normoxic hypoxic conditions. mediated significantly improved anti-programmed death-ligand 1 (α-PD-L1) treatment elicited abscopal effects in mouse model colorectal cancer, resulting >90% regression tumors. Mechanistic studies revealed that induced significant infiltration cytotoxic T cells.