Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria

• DOI: 10.1021/jacs.8b05354
• Publication Date: 2018-07-12T16:25:23Z
• Authors: Kenichi Matsuda; Takeo Tomita; Kazuo Shin-ya; Toshiyuki Wakimoto; Tomohisa Kuzuyama; Makoto Nishiyama
• Keywords: Hydrazine (antidepressant); Natural product; Hydrazone

Recent studies described several different routes that facilitate nitrogen-nitrogen bond formation in natural product biosynthesis. We report herein the identification of unprecedented machinery for hydrazine involved biosynthesis s56-p1, a dipeptide with unique hydrazone unit. The gene cassette comprising this is widespread across bacterial phyla, highlighting overlooked potential bacteria to synthesize hydrazine.