A Mild and Direct Site-Selective sp2 C–H Silylation of (Poly)Azines

• DOI: 10.1021/jacs.8b12063
• Publication Date: 2018-12-18T18:20:57Z
• Authors: Yiting Gu; Yangyang Shen; Cayetana Zarate; Ruben Martin
• Keywords: Reactivity; Surface Modification; Simplicity

A base-mediated protocol that allows for the site-selective sp2 C–H silylation of azines is described. This method distinguished by its mild conditions, simplicity and excellent modulation a diverse set azines, even in context late-stage functionalization, while exhibiting orthogonal reactivity with classical reactions.