Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes

• DOI: 10.1021/jacs.9b03863
• Publication Date: 2019-04-19T15:22:39Z
• Authors: Zhi-Xiong Tian; Jin-Bao Qiao; Guang-Li Xu; Xiaobo Pang; Liangliang Qi; Wei-Yuan Ma; Zhen-Zhen Zhao; Jicheng Duan; Yun-Fei Du; Peifeng Su; Xue-Yuan Liu; Xing-Zhong Shu
• Keywords: 01 natural sciences; 0104 chemical sciences

Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent of racemic alkyl electrophiles. Here, we report an enantioselective aryl-alkenylation reaction unactivated alkenes. This method provides access number biologically important chiral molecules such as dihydrobenzofurans, indolines, indanes. The incorporated alkenyl group is suitable for further that can lead increase molecular diversity complexity. proceeds under mild conditions at room temperature, easily accessible pyrox ligand used afford products high enantioselectivity. synthetic utility this demonstrated by enabling the modification complex peptides, indometacin, steroids.