Improvement of Obesity Phenotype by Chinese Sweet Leaf Tea (Rubus suavissimus) Components in High-Fat Diet-Induced Obese Rats

• DOI: 10.1021/jf103497p
• Publication Date: 2010-12-07T16:13:30Z
• Authors: Gar Yee Koh; Kathleen McCutcheon; Fang Zhang; Dong Liu; Carrie A. Cartwright; Roy Martin; Peiying Yang; Zhijun Liu
• Keywords: Ellagic Acid

Drinking an herbal tea to lose weight is a well-liked concept. This study was designed examine the possible improvement of obesity phenotype by new represented its purified components, gallic acid, ellagic and rubusoside (GER). Male obese-prone SD rats were given low-fat diet, high-fat or diet plus GER at dose 0.22 g/kg body for 9 weeks. significantly reduced gain 22% compared control group with 48% less abdominal fat gain. Food intake not affected. Blood glucose lowered in GER-treated group, whereas serum triglycerides cholesterol 50%. improved may be associated attenuated expression vascular endothelial growth factor preadipocyte 3T3-L1 cells. Although other underlying, possibly multiple, mechanisms behind are largely unknown, observed multiple obesity-related parameters warrants further investigations.