Discovery and Biological Evaluation of a New Family of Potent Modulators of Multidrug Resistance: Reversal of Multidrug Resistance of Mouse Lymphoma Cells by New Natural Jatrophane Diterpenoids Isolated from Euphorbia Species

• DOI: 10.1021/jm0111301
• Publication Date: 2002-07-26T06:10:30Z
• Authors: Judit Hohmann; Joseph Molnár; Dóra Rédei; Ferenc Evanics; Peter Forgo; Alajos Kálmán; Gyula Argay; Pál Szabó
• Keywords: Euphorbiaceae; Heteronuclear molecule; Euphorbia; Homonuclear molecule

The effects of 15 jatrophane diterpene polyesters (1−3 and 5−16) isolated from lipophilic extracts Euphorbia serrulata, E. esula, salicifolia, peplus (Euphorbiaceae) on the reversion multidrug resistance mouse lymphoma cells were examined. structures five new compounds (1−5) elucidated by spectroscopic methods, including HRFABMS, ESIMS, 1H−1H homonuclear 1H−13C heteronuclear correlations, long-range correlation spectra, NOESY experiments. stereochemistry absolute configuration one compound (3) determined X-ray crystallography. structure−activity relationship is discussed.