Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo

• DOI: 10.1021/jm050973f
• Publication Date: 2006-02-16T05:28:17Z
• Authors: Andrew V. Stachulski; Neil G. Berry; A. C. Lilian Low; Shelley L. Moores; Eleanor Row; David C. Warhurst; Ipemida S. Adagu; Jean-François Ros...
• Keywords: Biochanin A; Antiparasitic; Cryptosporidium parvum; In vitro toxicology

We report the preparation and antiparasitic activity in vitro vivo of a series isoflavone derivatives related to genistein. These analogues retain 5,7-dihydroxyisoflavone core genistein: direct genistein (2-H isoflavones), 2-carboethoxy isoflavones, precursor deoxybenzoins were all evaluated. Excellent against Cryptosporidium parvum was observed for both classes isoflavones cell cultures, lead compound 19, RM6427, shows high efficacy an experimental infection.