A Closer Look at the Structure of Sterically Stabilized Liposomes: A Small-Angle X-ray Scattering Study

• DOI: 10.1021/jp9109207
• Publication Date: 2010-04-29T16:06:41Z
• Authors: Zoltán Varga; Szilvia Berényi; Bálint Szokol; László Őrfi; György Kéri; István Peták; Armin Hoell; Attila Bóta
• Keywords: Small-angle X-ray scattering; Small-Angle Scattering; Biological small-angle scattering

The evaluation of the radial electron density profile a drug containing sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize hydrophilic shell polyethylene glycol chains. Gaussian model for describing along normal bilayer, got an asymmetric distribution PEGylated lipids in accordance with theoretical considerations. Moreover, used anomalous scattering study localization hydrophobic (a kinase inhibitor), which revealed that these molecules are mainly located hydrocarbon chain region phospholipid bilayer.