Design of Novel BSA/Hyaluronic Acid Nanodispersions for Transdermal Pharma Purposes

• DOI: 10.1021/mp400657g
• Publication Date: 2014-03-20T22:09:34Z
• Authors: Madalena Martins; Nuno G. Azoia; Ulyana Shimanovich; Teresa Matamá; Andreia C. Gomes; Carla Silva; Artur Cavaco-Paulo
• Keywords: Bovine serum albumin; Ex vivo; Dermal fibroblast; Penetration (warfare)

A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation histological sections revealed ability BSA/HA nanodispersions to cross stratum corneum penetrate into dermis. Furthermore, no significant toxicity found fibroblast keratinocyte cells vitro. These results proved potential for delivery constituting a high value biopharmaceutical cosmetics industries.