Triazole and Dihydroimidazole Alkaloids from the Marine Sediment-Derived Fungus Penicillium paneum SD-44

• DOI: 10.1021/np200037z
• Publication Date: 2011-04-15T15:12:04Z
• Authors: Chun-Shun Li; Chun-Yan An; Xiao-Ming Li; Shu-Shan Gao; Chuan-Ming Cui; Hao-Fen Sun; Bin-Gui Wang
• Keywords: Quinazolinone; Derivative (finance); Triazole

A novel triazole carboxylic acid, penipanoid (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), a very recently reported derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures elucidated by spectroscopic analysis, structure for 1 was confirmed X-ray crystallographic analysis. Compound represents first example of fungi, compound 2 is rare having dihydroimidazole ring system. The cytotoxicity compounds 4 antimicrobial activity 1–4 evaluated.