Cytoglobosins A−G, Cytochalasans from a Marine-Derived Endophytic Fungus, Chaetomium globosum QEN-14

• DOI: 10.1021/np900569t
• Publication Date: 2010-03-12T18:17:28Z
• Authors: Chuan-Ming Cui; Xiao-Ming Li; Chun-Shun Li; Peter Proksch; Bin-Gui Wang
• Keywords: Chaetomium globosum; Chaetomium

Cytoglobosins A−G (1−7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin Fex (9), were isolated identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived marine green alga Ulva pertusa. The structures natural products as well their relative configurations elucidated on basis 1D 2D NMR spectra (COSY, HSQC, HMBC, NOESY) HRESIMS data. C (3 4) displayed cytotoxic activity against A-549 tumor cell line.