ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis

• DOI: 10.1021/ol026008q
• Publication Date: 2002-07-26T06:10:30Z
• Authors: Erik Årstad; Anthony G. M. Bar...; Brian T. Hopkins; Johannes Köbberling
• Keywords: 01 natural sciences; 0104 chemical sciences

[reaction: see text] ROMPgel-supported triphenylphosphine was synthesized in three steps (67%) from norbornadiene, 4-bromoiodobenzene, and chlorodiphenylphosphine. The supported reagent has a high loading (2.5 mmol/g) favorable swelling properties organic solvents. It been utilized for the conversion of alcohols to halides, reduction ozonides, isomerization alpha,beta-acetylenic esters Staudinger reaction. In general, filtration resin reaction mixtures evaporation gave corresponding products yield purity.