New Experimental Conditions for Tandem hydroalumination/Cu-Catalyzed Asymmetric Conjugate Additions to β-Substituted Cyclic Enones

• DOI: 10.1021/ol200898c
• Publication Date: 2011-05-18T13:29:54Z
• Authors: Daniel Müller; Matthieu Tissot; Alexandre Alexakis
• Keywords: Stereocenter; Conjugate; Tandem

Readily available alkenylalanes, arising from hydroalumination of unprotected terminal alkynes, have been directly employed for the copper-catalyzed asymmetric conjugate addition (ACA) to β-substituted cyclic enones. The desired products, containing a quaternary stereogenic center, are generally obtained in good yields and enantioselectivities.