Structures of the Dimeric and Monomeric Chromanones, Gonytolides A–C, Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses

• DOI: 10.1021/ol2018449
• Publication Date: 2011-08-09T12:40:50Z
• Authors: Haruhisa Kikuchi; Masato Isobe; Mizuki Sekiya; Yuko Abe; Tsuyoshi Hoshikawa; Kazunori Ueda; Shoichiro Kurata; Yasuhiro Katou; Yoshiteru Oshima
• Keywords: Models, Molecular; Molecular Structure; Cell Survival; Endothelial Cells; Stereoisomerism; Crystallography, X-Ray; 01 natural sciences; Immunity, Innate; 3. Good health; 0104 chemical sciences; Animals; Cytokines; Humans; Drosophila; Mitosporic Fungi; Dimerization; Immunosuppressive Agents

Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as immune promoter from fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production IL-8 in human umbilical vein endothelial cells.