Calcium-Catalyzed Diastereo- and Enantioselective 1,4-Addition of Glycine Derivatives to α,β-Unsaturated Esters

• DOI: 10.1021/ol702958w
• Publication Date: 2008-01-29T11:01:10Z
• Authors: Shū Kobayashi; Tetsu Tsubogo; Susumu Saito; Yasuhiro Yamashita
• Keywords: Derivative (finance); Glutamic acid

The first highly diastereo- and enantioselective catalytic asymmetric 1,4-addition reactions of a glycine Schiff base to β-substituted α,β-unsaturated esters have been developed. reaction pathway was successfully controlled, the desired products were exclusively obtained with high enantioselectivities. product converted 3-substituted glutamic acid derivative by hydrolysis.