Sensitivity to methacholine and capsaicin in patients with unclear respiratory symptoms

• DOI: 10.1034/j.1398-9995.2002.23380.x
• Publication Date: 2003-03-11T01:49:31Z
• Authors: E. Ternesten‐Hasséus; A. Farbrot; O. Löwhagen; EVA Millqvist
• Keywords: Methacholine; Capsaicin; Cough reflex

Background: Capsaicin, the pungent ingredient in red pepper, is known to stimulate coughing via sensory nervous system. Earlier studies showed that patients with airway symptoms induced by chemicals and strong scents cough more after inhalation of capsaicin than healthy control subjects this has been interpreted as a hyperreactivity nerves. Our aim was study sensitivity inhaled occurrence who underwent bronchial methacholine test, primarily because suspected asthma. Methods: Fifty‐two consecutive referred for testing were also provoked increasing concentrations. Cough compared 40 subjects. Results: The coughed significantly each dose ( P < 0.0001). Twelve (23%) had positive these, nine diagnosed There no difference between sensitive or insensitive methacholine. Conclusions: majority increased but did demonstrate (SHR). SHR appears be common diagnosis investigations obscure symptoms.