Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family‐based association study in a Spanish population

• DOI: 10.1034/j.1399-0004.2002.620309.x
• Publication Date: 2003-03-11T11:30:09Z
• Authors: E González‐Pérez; M Via; A López‐Alomar; E Esteban; N Valveny; M Bao; E Domingo; P Moral
• Keywords: Ischaemic heart disease; Transmission disequilibrium test

The effect of the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene, traditionally associated with ischaemic heart disease (IHD), was assessed a Spanish population. transmission disequilibrium test (TDT) used to determine possible association sample 101 trios IHD patients. distribution MTHFR genotypes similar subjects and parental group; TT genotype present 14.9% patients, as compared 15.2% parents. frequency T allele also cases parents (39.6% vs. 42.4%; p = 0.649). TDT confirmed that observed did not deviate significantly from expected one (χ 2 0.743; > 0.4). Our analysis clearly demonstrates lack between mutation cardiovascular artery disease, both for general group different risk subgroups (smokers, hypertension, male sex, overweight type A behaviour pattern)