Study of host‐ and virus‐related factors associated with spontaneous hepatitis C virus clearance

• DOI: 10.1034/j.1399-0039.2000.560207.x
• Publication Date: 2003-03-12T20:54:35Z
• Authors: L. Alric; M. Fort; J. Izopet; J.‐P. Vinel; C. Bureau; K. Sandre; J.‐P. Charlet; M. Beraud; M. Abbal; M. Duffaut
• Keywords: Host factors; Univariate analysis; Viral Hepatitis

Epidemiologic parameters, virologic characteristics and frequency of HLA class II DR DQ antigens were compared between 63 subjects with spontaneous hepatitis C virus clearance (group 1) 282 patients chronic active infection 2). DRB1*1101 moreover DQB1*0301 alleles more frequent in group 1 than 2 (33.8% vs. 14.7% 64.4% 28.6%; P=0.012 P=0.003, respectively). The DQB1*02 was lower (25.4% 49%; P=0.04). No difference observed viral genotype distribution 2. Univariate analysis showed that female sex contamination by intravenous drug use associated self limited infection. However, multivariate analysis, the only independent factor RNA (P=0.004). In conclusion, is determined (mainly DQB1*0301) sex, while plays no role.