A new allele within the transmembrane region of the human MICA gene with seven GCT repeats

• DOI: 10.1034/j.1399-0039.2002.600608.x
• Publication Date: 2003-03-12T20:58:31Z
• Authors: B. Rueda; M. Pascual; M.A. López‐Nevot; E. González; J. Martín
• Keywords: 0301 basic medicine; Celiac Disease; 03 medical and health sciences; Polymorphism, Genetic; Base Sequence; Trinucleotide Repeats; Histocompatibility Antigens Class I; Molecular Sequence Data; Humans; Microsatellite Repeats

Abstract: Major histocompatibility complex class I chain‐related genes (MIC) belong to a multicopy gene family located within the HLA region of chromosome 6. They encode for proteins that have completely different organization, expression, and products from classical products. One member this is MICA gene, which characterized by its high degree polymorphism, with over 50 alleles described. Moreover, exon 5 presents microsatellite polymorphism consisting variable number GCT repeats 4, 5, 6, 9, or 10 alanine residues, variant (MICA A5.1) includes nucleotide insertion (GCT→GGCT). In study, we report novel allele in transmembrane seven found based study celiac disease.