Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis

• DOI: 10.1034/j.1399-3003.1999.14b24.x
• Publication Date: 2003-03-11T20:11:46Z
• Authors: K Iyonaga; M Suga; T Yamamoto; H Ichiyasu; H Miyakawa; M Ando
• Keywords: Pulmonary alveolar proteinosis; Pulmonary alveolus

Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown aetiology characterized by accumulations lipoproteinaceous material within the alveoli. The macrophages become increasingly foamy, and are thought to have role in pathogenesis PAP. However, mechanisms macrophage recruitment unclear. In bronchoalveolar lavage fluid (BALF) four patients with PAP 20 normal control subjects, following were examined: monocyte chemotactic activity due chemokine chemoattractant protein (MCP)-1 use chamber assay, levels MCP-1 enzyme-linked immunosorbent expression on cells immunocytochemistry situ hybridization. BALF was markedly elevated, completely absorbed treatment anti-MCP-1. surprisingly high group (25,100+/-472 pg x mL(-1)), whereas low detected subjects (mean: never smokers 4.8; 10.4 mL(-1)). messenger ribonucleic acid expressed from patients, reduced according foaming cells; there monocyte-like strong expression, small foamy moderate large faint MCP-1, ghost no expression. increase number relatively small. These data suggest that protein(-1) represents an amplification mechanism for additional alveoli pulmonary proteinosis. It possible ingestion excess materials may impair function survival, resulting lack prominent fluid.