Simple and stereospecific homologation of urethane‐protected α‐amino acids to their higher homologs using HBTU1
Diazomethane
Stereospecificity
Hexafluorophosphate
Benzotriazole
Alpha (finance)
DOI:
10.1034/j.1399-3011.2003.00052.x
Publication Date:
2010-11-12T17:43:38Z
AUTHORS (2)
ABSTRACT
Abstract: A simple, efficient and stereospecific approach for the homologation of urethane‐protected α ‐amino acids to β‐amino by Arndt–Eistert method employing Fmoc‐/Boc‐ acid 2‐(1H‐benzotriazole‐1‐yl)‐1,1,3,3‐tetramethyl‐uronium hexafluorophosphate mixture acylation diazomethane synthesizing key intermediates ‐aminodiazomethanes as crystalline solids is described.
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