Cow's milk protein intolerance and chronic constipation in children

• DOI: 10.1034/j.1399-3038.2001.0o057.x
• Publication Date: 2002-07-26T07:53:57Z
• Authors: Silvia Daher; Soraia Tahan; Dirceu Solé; Charles K. Naspitz; Francy Reis Da Si...; Ulysses Fagundes ...; Mauro Batista De ...
• Keywords: Radioallergosorbent test; Milk allergy; Elimination diet

Cow's milk protein (CMP) allergy was investigated in 25 children (age‐range 3 months to 11 years) with chronic constipation. A diagnosis of constipation made on the basis a history painful elimination hard stools for at least 1 month, whether or not associated reduced frequency soiling. The were evaluated using clinical parameters and following laboratory tests: total serum immunoglobulin E (IgE); specific IgE (radioallergosorbent test [RAST]) whole cow's milk, α‐lactoalbumin, β‐lactoglobulin, food group; skin‐prick tests casein. Following evaluation, submitted CMP‐free diet period 4 weeks. In seven patients (28%), disappeared during reappeared within 48–72 h challenge milk. two infants rectal biopsy revealed allergic colitis they therefore did undergo challenge. High levels observed five who showed improvement (71%), positive skin‐test (29%), detectable (29%). These results suggest that CMP intolerance should be considered as cause refractory children, although underlying mechanism still require further investigation.