Distribution of intrathecal catheter positions in rat

• DOI: 10.1034/j.1399-6576.2001.045005608.x
• Publication Date: 2003-03-10T09:46:07Z
• Authors: F. Asato; M. Butler; H. Blomberg; T. Gordh
• Keywords: Subarachnoid space; Intrathecal

Background: Although drug administration through an intrathecal catheter is widely used in the study of spinal pharmacology, positions transverse plane that may cause a limited spread solution remain unclear. In first step to clarify this issue, distribution position was investigated rats. Methods: A polyethylene (PE‐10) inserted intrathecally 8.5 cm atlanto‐occipital membrane, aiming tip dorsal surface cord. Three or four weeks after implantation catheter, 83 rats were transcardiacally perfused with fixative solution. The longitudinally and transversely by cutting cord segmentally intervertebral disk at different levels. Results: Seventeen excluded from further data analysis. Transversely, catheters located left lateral subarachnoid space 23 (35%), right 15 (23%), 22 (33%), ventral 6 (9%). Longitudinally, significantly higher group (median, T9) than (T11/12) ( P <0.01). Conclusion: Chronic variously rat plane, placement (58%) frequently observed, whereas occurred 33%.