Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis

• DOI: 10.1034/j.1600-0404.2000.102003175.x
• Publication Date: 2003-03-11T02:24:53Z
• Authors: S. Mizuno; Y. Takahashi; Z. Kato; H. Goto; N. Kondo; H. Hoshi
• Keywords: Creatine; Proton magnetic resonance

The histological features of cortical tubers in patients with tuberous sclerosis (TS) were studied by the proton magnetic resonance spectroscopy (MRS).The subjects 4 children, mean age 10 years, clear evidence on MRI and SPECT. Four age-matched control children served as subjects. Spectra acquired over tuber using short TE.The myoinositol/creatine ratios TS significantly increased compared those (P < 0.02). NAA/creatine decreased 0.02).The decrease was considered to reflect a reduction cranial neurons. increase thought an glial cells. Proton MRS might play role estimation changes neurological diseases.