Regeneration of nerve fibres in the peri‐implant epithelium incident to implantation in the rat maxilla as demonstrated by immunocytochemistry for protein gene product 9.5 (PGP9.5) and calcitonin gene‐related peptide (CGRP)

• DOI: 10.1034/j.1600-0501.2003.140216.x
• Publication Date: 2004-12-22T04:42:59Z
• Authors: Noritaka Fujii; Hideo Ohnishi; Masaki Shirakura; Shuichi Nomura; Hayato Ohshima; Takeyasu Maeda
• Keywords: Junctional epithelium

Abstract: The response of nerve fibres in the peri‐implant epithelium to titanium implantation was investigated with an experimental model using rat maxilla and immunohistochemical techniques. latter employed antibodies protein gene product 9.5 (PGP9.5), calcitonin gene‐related peptide (CGRP). In control rats without implantation, a dense innervation PGP9.5‐ CGRP‐positive recognized throughout junctional epithelium, as has been previously reported. A titanium‐implantation induced remarkable inflammatory reaction, well destruction covering epithelial cells. By 3–5 days post‐implantation, reaction showed tendency disappear, proliferation down‐growth along implant. At this stage, no were found around epithelium. 10 days, few reached basal cell layers entered it 15 after when cells morphological features roughly resembling those normal complete osseointegration stage (days 20–30), fibres, thin beaded appearance, distributed After 20 numerical density intraepithelial nerves appeared same as, or less than, that These findings indicate shows might have diverse functions, which suggested literature.