Perceptual anomalies in schizophrenia co-occur with selective impairments in the gamma frequency component of midlatency auditory ERPs.

• DOI: 10.1037/0021-843x.117.1.106
• Publication Date: 2008-02-12T14:30:43Z
• Authors: Jason K. Johannesen; Misty Bodkins; Brian F. O'Donnell; Anantha Shekhar; William P. Hetrick
• Keywords: Sensory gating

This study aimed to establish concordance between phenomenological and psychophysiological indices of sensory gating disturbance in schizophrenia. Perceptually normal deviant subgroups schizophrenia (SZ) healthy comparison (HC) participants were empirically determined on the basis self-rated Sensory Gating Inventory scores. Contrasts by diagnosis subgroup classification conducted event-related brain potential (ERP) response attenuation paired auditory stimuli, measured time (P50 ERP) frequency (low frequency, 1-20 Hz; gamma band, 20-50 Hz) domains. The SZ sample evidenced significantly less low-frequency than did HC but comparable P50 responses. response, however, appeared insensitive variation perceptual experience subgroups. Conversely, smaller amplitude weaker distinguished (n=17) from (n=9) (n=29) statistically equivalent across all comparisons. These findings support hypotheses relating an early input dysfunction, which is thought involve gamma-mediated thalamocortical integration stimuli.