Formation of Prothrombin Converting Activity

• DOI: 10.1038/215248a0
• Publication Date: 2006-07-06T05:53:27Z
• Authors: H. C. HEMKER; M. P. ESNOUF; P. W. HEMKER; A. C. W. SWART; R. G. MACFARLANE
• Keywords: Kinetics; Binding Sites; Thrombin; Factor V; Prothrombin; Factor VII; Blood Coagulation; Models, Biological; Phospholipids

After measurement of the conversion of prothrombin to thrombin in a purified system, a model has been constructed for the kinetics of the formation of prothrombin converting activity. In the model phospholipid provides a surface on to which coagulant factors bind.