Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

• DOI: 10.1038/348411a0
• Publication Date: 2003-06-12T22:58:15Z
• Authors: Jiahuai Wang; Youwei Yan; Thomas P. J. Garrett; Jinhuan Liu; David W. Rodgers; Robert L. Garlick; George E. Tarr; Yasmin Husain; Ellis L. Reinherz; Stephen C. Harrison
• Keywords: Immunoglobulin domain; Fragment (logic)

The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.