Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry

• DOI: 10.1038/clpt.2012.139
• Publication Date: 2012-09-05T10:42:04Z
• Authors: V Perera; A S Gross; A J McLachlan
• Keywords: Paraxanthine

The drug-metabolizing enzyme CYP1A2 contributes to the metabolism of a number commonly used medicines and displays wide interindividual variability. aim this study was investigate activity in population South Asian ancestry compare it with European ancestry. determined using 4 h paraxanthine/caffeine saliva concentration ratio following 100-mg oral dose caffeine healthy individuals (n = 166) Participants were surveyed for extrinsic ethnic factors genotyped polymorphisms related genes. Significantly lower observed participants (median: 0.42; range: 0.10–1.06) as compared (0.54; 0.12–1.64) (P < 0.01). Multiple linear regression indicated that 41% variability could be explained by diet, lifestyle, genetic studied. Clinical Pharmacology & Therapeutics (2012); 92 4, 511–519. doi:10.1038/clpt.2012.139