Reelin induces EphB activation

• DOI: 10.1038/cr.2013.7
• Publication Date: 2013-01-15T11:40:33Z
• Authors: Elisabeth Bouché; Mario I Romero-Or...; Mark Henkemeyer; Timothy Catchpole; Jost Leemhuis; Michael Frotscher; Petra May; Joachim Herz; Hans H Bock
• Keywords: DAB1

The integration of newborn neurons into functional neuronal networks requires migration cells to their final position in the developing brain, growth and arborization processes formation synaptic contacts with other neurons. A central player among signals that coordinate this complex sequence differentiation events is secreted glycoprotein Reelin, which also modulates plasticity, learning memory adult brain. Binding Reelin ApoER2 VLDL receptor, two members LDL receptor family, initiates a signaling cascade involving tyrosine phosphorylation intracellular cytoplasmic adaptor protein Disabled-1, targets cytoskeleton ultimately controls positioning throughout However, it possible interact receptor-mediated cascades regulate different aspects brain development plasticity. EphB kinases cell adhesion repulsion-dependent via bidirectional through ephrin B transmembrane proteins. Here, we demonstrate binds extracellular domains proteins, inducing clustering activation forward neurons, independently 'classical' receptors, VLDLR. Accordingly, mice lacking EphB1 EphB2 display defect CA3 hippocampal pyramidal similar Reelin-deficient mice, depends on kinase activity Together, our data provide biochemical evidence for signal between signaling.