Induction of the Wnt Antagonist, Dickkopf-1, Contributes to the Development of Neuronal Death in Models of Brain Focal Ischemia

• DOI: 10.1038/jcbfm.2008.111
• Publication Date: 2008-10-01T08:02:54Z
• Authors: Federica Mastroia...; Carla L Busceti; Francesca Biagioni; Slavianka G Moyanova; Miriam H Meisler; Giuseppe Battaglia; Andrea Caricasole; Valeria Bruno; Ferdinando Nicoletti
• Keywords: Penumbra; Brain ischemia; Pathophysiology; Stroke

Inhibition of the canonical Wnt pathway has been implicated in pathophysiology neuronal death. Here, we report that secreted antagonist, Dickkopf-1 (Dkk-1) is rapidly induced neurons after induction focal brain ischemia. In rats undergoing transient ischemia response to infusion endothelin-1, Dkk-1 was ischemic core and penumbra region. Induction associated with a reduced expression beta-catenin (a downstream signaling molecule pathway), not observed expressing protective protein, heat shock protein-70. Treatment lithium ions, which, inter alia, rescue pathway, highly against damage. also cortical mice permanent middle cerebral artery (MCA) occlusion. This model allowed us compare wild-type doubleridge mice, which are characterized by Dkk-1. Doubleridge showed an attenuated reduction infarct volume MCA occlusion, providing direct demonstration contributes These data rise interesting possibility antagonists or drugs might be neuroprotective stroke.