Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis

• DOI: 10.1038/mi.2015.108
• Publication Date: 2015-11-04T13:22:04Z
• Authors: R Mora-Buch; I Dotti; N Planell; E Calderón-Gómez; P Jung; M C Masamunt; J Llach; E Ricart; E Batlle; J Panés; A Salas
• Keywords: Paneth cell; Intestinal mucosa; Homeostasis

Ulcerative colitis (UC) is a chronic intestinal inflammatory disease that may undergo periods of activity followed by remission. We aimed to identify the endogenous regulatory mechanisms promote Transcriptional and protein analysis mucosa revealed IL-1 decoy receptor, interleukin-1 receptor type 2 (IL1R2), was upregulated in remission compared with active UC controls. identified epithelial cells as being responsible for increased IL-1R2 production during Expression IL1R2 negatively regulated Wnt/beta-catenin signals colonic crypts or stem cell cultures; accordingly, upon differentiation. Blocking isolated crypt cultures patients T-cell stimulated biopsy supernatant from boosted IL-1β-dependent inflammation-related cytokines. Finally, transcription significantly lower relapsed 1-year follow-up period those endoscopic Collectively, our results reveal IL-1/IL-1R2 axis differentially remitting patients. hypothesize presence low concentrations IL-1β act locally regulator homeostasis.