Histopathologic findings associated with APOL1 risk variants in chronic kidney disease

• DOI: 10.1038/modpathol.2014.92
• Publication Date: 2014-08-01T12:39:46Z
• Authors: Christopher P Larsen; Marjorie L Beggs; Mohammad Saeed; Josephine M Ambruzs; L Nicholas Cossey; Nidia C Messias; Patrick D Walker; Barry I Freedman
• Keywords: Glomerulosclerosis; Histopathology

The effects of nephropathy risk variants in the apolipoprotein L1 gene (APOL1) on renal histopathology African Americans with arterionephrosclerosis or putative 'hypertension-associated' are unknown. APOL1 genotype-phenotype correlations were performed a blinded manner from biopsies 196 self-reported kidney biopsy at large national nephropathology practice. Subjects had chronic disease without nephrotic syndrome. A discovery analysis compared histopathologic changes glomerular and tubulointerstitial compartments 58 subjects 2 versus 56 0 variants. Validation was 82 additional 0, 1, Two variant zero group genotype associations subphenotypes assessed by χ(2) analyses. ANOVA means continuous variables. In analyses, significantly less obsolescent glomerulosclerosis, more (solidified disappearing) thyroidization-type tubular atrophy, microcystic dilatation seen patients two alleles. Greater degrees arteriosclerosis present those Segmental glomerulosclerosis did not differ between groups. Presence following discriminatory findings discovery, that is, <50% dilatation, specific for presence alleles validation phase. who possess often lack have greater dilation than fewer These support involvement multiple cell types subnephrotic forms APOL1-associated nephropathy, particularly tubule cells resultant disease.