Perceived threat predicts the neural sequelae of combat stress

• DOI: 10.1038/mp.2010.132
• Publication Date: 2011-01-18T09:05:53Z
• Authors: G A van Wingen; E Geuze; E Vermetten; G Fernández
• Keywords: Stressor; Ventromedial prefrontal cortex

Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead positive outcomes others. However, it remains unknown how stress affects neural functioning humans and what factors mediate individual differences sequelae of stress. The amygdala is a key brain region involved threat detection fear regulation, previous animal studies have suggested that sensitizes responsivity reduces its regulation by prefrontal cortex. In this study, we used prospective design investigate consequences soldiers before after deployment combat zone. We found increased insula reactivity biologically salient stimuli across group combat-exposed individuals. contrast, influence on coupling with dorsal anterior cingulate cortex was dependent perceived threat, rather than actual exposure, suggesting appraisal interoceptive awareness regulation. Our results demonstrate has sustained responsivity, suggest role an amygdala-centered network aftermath